Bun 29 Mg/dl 6 - 26 Mg/dl Is This Reading Dangerous to Kidneys

Subconscious Causes of Loftier or Low Blood Urea Nitrogen (BUN)

Testing urea levels in the claret provides information nigh your health. This post covers the causes of loftier and depression blood urea nitrogen (BUN) and what they may mean for you.

What is Blood Urea Nitrogen (BUN)?

Blood urea nitrogen (BUN) is a measure of the corporeality of urea in the blood [one].

The liver produces urea equally a waste product of proteins breakup. It binds excess nitrogen from used-upwards proteins and safely removes it from the trunk [i, two].

Urea is created not only from dietary protein, but also from protein in your tissues [3].

On a normal nutrition, we produce about 12 g of urea each twenty-four hour period [two].

The bulk of the urea, well-nigh 10 1000 each day, is eliminated by the kidneys [2].

Being a diuretic, urea helps the kidneys apace flush water and other compounds [4, v].

A small amount of urea (less than 0.five g/day) is lost through the gut, lungs, and skin. During do, a substantial corporeality may be lost through sweat [2].

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BUN Blood Test

Why Doctors Social club it

A blood urea nitrogen (BUN) exam is performed to:

• Encounter if your kidneys are working normally or if kidney disease is progressing
• Check for astringent dehydration

Any standard blood test will take BUN or urea numbers.

Conventional doctors will wait at high or low BUN numbers and not mention anything, just these tin can signal that sure processes in the body aren't optimal.

What Your BUN Levels Mean

BUN levels correspond the balance between [half-dozen]:

• Urea production (in the liver)
• Urea breakdown, and
• Urea elimination (via the kidneys)

Therefore, BUN is an indicator of kidney health and/or liver health.

However, creatinine is a much more reliable marking of kidney function. BUN is far more likely to be affected past dietary and physiologic conditions unrelated to kidney function [2].

Optimal and Normal Range

Lab results are usually shown as a gear up of values known equally a reference range, which is sometimes referred to equally a "normal range." A reference range includes upper and lower limits of a lab test based on a group of otherwise healthy people.

Your healthcare provider volition compare your lab test results with reference values to see if any of your results fall outside the range of expected values. Past doing and so, you and your healthcare provider can gain clues to assist identify possible conditions or diseases.

In Europe, the whole urea molecule is measured, whereas in the U.s.a. merely the nitrogen component of urea is measured (the blood or serum urea nitrogen, i.e., BUN or SUN) [3].

The BUN is roughly half of the blood urea [iii].

Normal homo adult blood should contain between 5 to xx mg of urea nitrogen per 100 ml (5 to xx mg/dL) of claret, or i.8 to 7.1 mmol urea per liter [3].

To convert from mg/dL of blood urea nitrogen to mmol/50 of urea, multiply past 0.357.

The range is wide because of normal variations due to poly peptide intake, protein breakdown, state of hydration, liver urea production, and urea elimination by the kidneys [three].

Decreased or elevated BUN concentrations are normally seen in pregnancy [7, 8].

BUN/Creatinine Ratio

A BUN exam is ordinarily done with a blood creatinine test.

The level of creatinine in your claret also tells how well your kidneys are working. A high creatinine level may indicate problems with the kidneys or middle, but if it's slightly elevated, it could simply mean that your nutrition is high in poly peptide [nine].

Blood urea nitrogen (BUN) and creatinine tests tin be used together to discover the BUN-to-creatinine ratio (BUN:creatinine).

In most cases, it's healthier to take a lower ratio of BUN to creatinine (ten:1 to 20:1) [9].

High BUN Levels

Symptoms

The urea nitrogen test is often ordered for people who are experiencing signs and symptoms of kidney disorders. These symptoms tin include:

• Frequent urination
• Discolored urine (bloody, dark, or foamy)
• Joint pain
• Bone pain
• Dorsum pain
• Muscle cramping
• Restless legs
• Fatigue
• Problem sleeping
• Poor appetite
• Swelling (especially in the extremities)
• Itchiness

Causes

The causes shown here take been associated with elevated BUN, simply this marker alone is non enough to diagnose any health condition. Practice not attempt to self-diagnose based on this lab marker. Work with your doctor to determine an accurate diagnosis and to develop an appropriate treatment or management strategy.

All the following can drag your BUN:

• Kidney illness or failure, and blockage of the urinary tract by a kidney stone [viii].
• High-protein nutrition [two]
• Fever or infection, which increases poly peptide breakup. Increased protein breakdown is a common feature of an disease. Protein breakdown is stimulated by hormones (such equally glucagon, epinephrine, and cortisol) and inflammatory cytokines. Protein production, on the other mitt, is reduced by lowering growth hormone, insulin, and testosterone levels [2, 6].
• Inflammation or interval training, which results in poly peptide breakdown from muscle
• Dehydration or low water consumption – I apply this as a measure of hydration in clients. BUN increases equally blood volume decreases [6].
• Stress – An inappropriate increment in the activation of the sympathetic, renin-angiotensin-aldosterone, and vasopressin systems elevate BUN, which is often seen in heart failure. Cortisol volition likewise increment protein breakdown and elevate BUN [10, 11].
• Gut bleeding -When upper GI bleeding occurs, the blood is digested to poly peptide. This protein is transported to the liver and metabolized to BUN [2, ane].
• Poor apportionment, which results in lower claret flow to the kidneys and therefore less of an ability to clear the urea [12, half-dozen].
• Thyroid abnormalities, which result in abnormal kidney function: hypothyroidism, and hyperthyroidism [13, fourteen].
• Glucocorticoids, Tetracyclines (except doxycycline) and other anti-anabolic drugs [ii]
• Lower growth hormone or IGF-1. IGF-i and growth hormone inhibit urea synthesis [fifteen].
• Severe burns

Negative Wellness Effects

You lot may be wondering why high BUN is bad.

To start with, elevated urea on its own has some agin effects. Urea in high concentrations can crusade oxidative stress in cells [16].

However, loftier BUN is also an indicator of other underlying weather.

High BUN indicates increased poly peptide breakup, which is associated with decreased immune function. A study shows that patients with elevated BUN (> 20 mg/dl) take an increased risk of infection [half-dozen].

Loftier BUN is associated with increased mortality in critically ill patients [6, 17, xviii, 19].

Elevated BUN is also associated with increased stroke risk in heart surgery, and adverse outcomes in atherosclerosis and centre failure patients [twenty, 21, 22].

Note that BUN values remain within the normal range until more than than 50% of renal function is lost. Inside that range, however, a doubling of the values (due east.g., BUN rising from viii to sixteen mg/dl) may hateful a 50% fall in kidney part [2].

How to Lower BUN

Nearly importantly, piece of work with your doctor to treat any underlying weather causing your high BUN levels. You may try the additional strategies listed beneath if you and your doc decide that they could be appropriate. None of these strategies should ever exist done in place of what your dr. recommends or prescribes.

Nutrition & Supplements

There are two main ways to decrease BUN:

• Drink more water
• Eat less protein

Depression BUN Levels

Causes

The causes shown hither have been associated with depression BUN, just this marker lonely is non plenty to diagnose whatsoever wellness condition. Practise not attempt to cocky-diagnose based on this lab mark. Work with your doctor to make up one's mind an accurate diagnosis and to develop an appropriate treatment or management strategy.

The following can excessively lower your BUN:

• Depression-protein diet, malnutrition, or starvation [ii]
• Impaired liver activity due to liver disease [2]
• Genetic deficiency of urea bike enzymes [2]
• Higher IGF-1 and growth hormone. These inhibit urea synthesis. Growth hormone-scarce children given homo growth hormone have lower urea nitrogen, and this is due to decreased urea synthesis [15, 23].
• Anabolic steroids, which decrease poly peptide breakdown
• Overhydration, or drinking a lot of water
• Pregnancy (due to increased plasma volume) [vii]

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Source: https://labs.selfdecode.com/blog/causes-of-high-or-low-blood-urea-nitrogen-bun/

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